This Brief takes the reader on a chemical journey by following the history for over two centuries of how an opiate became an opioid, thus spawning an empire and a series of crises. These imperfect resemblances of alkaloids are both natural and synthetic substances that, particularly in America, are continually part of a growing concern about overuse. This seemed an inviting prospect for those in pain, but as the ubiquitous media coverage continues to lay bare, the levels of abuse point to the fact that perhaps an epidemic is upon us, if not a culture war. Seeking answers to how and why this addiction crisis transpired over two hundred years of long development, this Brief examines the role that the chemistry laboratory played in turning patients into consumers. By utilizing a host of diverse sources, this Brief seeks to trace the design and the production of opioids and their antecedents over the past two centuries. From the isolation and development of the first alkaloids with morphine that relieved pain within the home and on the battlefield, to the widespread use of nostrums and the addiction crisis that ensued, to the dissemination of drugs by what became known as Big Pharma after the World Wars; and finally, to competition from home-made pharmaceuticals, the progenitor was always, in some form, a type of chemistry lab. At times, the laboratory pressed science to think deeply about society's maladies, such as curing disease and alleviating pain, in order to look for new opportunities in the name of progress. Despite the best intentions opioids have created a paradox of pain as they were manipulated by creating relief with synthetic precision and influencing a dystopian vision. Thus, influence came in many forms, from governments, from the medical community, and from the entrepreneurial aspirations of the general populace. For better, but mostly for worse, all played a role in changing forever the trajectory of what started with the isolation of a compound in Germany. Combining chemistry and history in a rousing new long-form narrative that even broadens the definition of a laboratory, the origins and future of this complicated topic are carefully examined.
The opioid epidemic is responsible for longest sustained decline in U.S. life expectancy since the time of World War I and the Great Influenza. In 2017, nearly 50,000 Americans died from an opioid overdose - with an estimated 2 million more living with opioid addiction every day. The Opioid Epidemic: What Everyone Needs to Know® is an accessible, nonpartisan overview of the causes, politics, and treatments tied to the most devastating health crisis of our time. Its comprehensive approach and Q&A format offer readers a practical path to understanding the epidemic from all sides: the basic science of opioids; the nature of addiction; the underlying reasons for the opioid epidemic; effective approaches to helping individuals, families, communities, and national policy; and common myths related to opioid addiction. Written by two expert physicians and enriched with stories from their experiences the crosshairs of this epidemic, this book is a critical resource for any general reader -- and for the individuals and families fighting this fight in their own lives.
Rothman-Simeone The Spine helps you achieve optimal outcomes in the clinical practice of spine surgery in adults and children. Drs. Harry N. Herkowitz, Steven R. Garfin, Frank J. Eismont, Gordon R. Bell, Richard Balderston, and an internationally diverse group of authorities help you keep up with the fast-paced field and get the best results from state-of-the-art treatments and surgical techniques, such as spinal arthroplasty and the latest spinal implants and equipment. An all-new full-color design and surgical videos online at www.expertconsult.com make this classic text more invaluable than ever before. Get the best results from the full range of both surgical and non-surgical treatment approaches with guidance from the world’s most trusted authorities in orthopaedic spine surgery. Find important information quickly through pearls, pitfalls, and key points that highlight critical points. Watch experts perform key techniques in real time with videos, on DVD and online, demonstrating minimally invasive surgery: SED procedure; thorascopic techniques; lumbar discectomy; pedicle subtraction osteotomy (PSO); C1, C2 fusion; intradural tumor; cervical laminoforaminoty; and much more. Apply the newest developments in the field thanks to expert advice on minimally invasive surgery, spinal arthroplasty and the latest spinal implants and equipments. See procedures clearly through an all new full-color design with 2300 color photographs and illustrations placed in context. Access the fully searchable contents of text online at www.expertconsult.com.
Drain's Perianesthesia Nursing: A Critical Care Approach, 6th Edition is the most comprehensive book on the market specifically tailored to perianesthesia nurses. The book features five distinct sections – the PACU, anatomy and physiology, pharmacology, nursing care, and special considerations. Nursing and pharmacologic interventions are integrated with in-depth coverage of pathophysiology. This edition expands coverage of evidence based research and adds a new chapter on care of the obese patient undergoing bariatric surgery. Written by Jan Odom-Forren, an expert in the anesthesia and post-operative fields, Drain's Perianesthesia Nursing is also an excellent study tool for ASPAN certification. Five separate sections provide coverage including the PACU, anatomy and physiology, pharmacology, nursing care, and special considerations. An overview of essential PACU concepts section covers issues such as patient safety, evidence-based research, and legal/ethical considerations Anatomy and physiology chapters cover physiologic considerations for each body system Pharmacology chapters cover basic principles as well as types of anesthetic agents such as intravenous anesthetics and regional anesthesia, including the physiology of action and the appropriate nursing interventions to prepare you for common situations in the PACU. Nursing care chapters cover assessment, patient education, complications, pain management, and care of specialty-surgery patients. A section on special considerations covers the care of patients of different ages and those with conditions such as malignant hyperthermia, substance abuse, and cardiac arrest. Coverage of current policies and issues affecting perianesthesia nursing practice includes patient safety, infection control, managed care implications, pain management, and bioterrorism. Nursing and pharmacologic interventions are integrated with in-depth coverage of pathophysiology for a comprehensive look at disease and treatment. NEW Evidence Based Research boxes are added to all the chapters in Section IV and Section V. NEW! Care of the Obese Patient Undergoing Bariatric Surgery chapter discusses the challenges that weight-loss surgery presents to the patient and perianesthesia nurse. Streamlined format includes an overview, chapter summary, and references for each chapter. More than 275 illustrations show key concepts and principles of care. Updated The Changing Health Care System and Its Implications for the PACU chapter includes content on healthcare reform. Revised Patient Safety and Legal Issues in the PACU chapter includes content on patient safety. Expanded Evidence-based Practice and Research and Bioterrorism and Its Impact on the PACU chapters include coverage of new developments and practices.
Behavioral Neuroscientists study the behavior of animals and humans and the neurobiological and physiological processes that control it. Behavior is the ultimate function of the nervous system, and the study of it is very multidisciplinary. Disorders of behavior in humans touch millions of people’s lives significantly, and it is of paramount importance to understand pathological conditions such as addictions, anxiety, depression, schizophrenia, autism among others, in order to be able to develop new treatment possibilities. Encyclopedia of Behavioral Neuroscience is the first and only multi-volume reference to comprehensively cover the foundation knowledge in the field. This three volume work is edited by world renowned behavioral neuroscientists George F. Koob, The Scripps Research Institute, Michel Le Moal, Université Bordeaux, and Richard F. Thompson, University of Southern California and written by a premier selection of the leading scientists in their respective fields. Each section is edited by a specialist in the relevant area. The important research in all areas of Behavioral Neuroscience is covered in a total of 210 chapters on topics ranging from neuroethology and learning and memory, to behavioral disorders and psychiatric diseases. The only comprehensive Encyclopedia of Behavioral Neuroscience on the market Addresses all recent advances in the field Written and edited by an international group of leading researchers, truly representative of the behavioral neuroscience community Includes many entries on the advances in our knowledge of the neurobiological basis of complex behavioral, psychiatric, and neurological disorders Richly illustrated in full color Extensively cross referenced to serve as the go-to reference for students and researchers alike The online version features full searching, navigation, and linking functionality An essential resource for libraries serving neuroscientists, psychologists, neuropharmacologists, and psychiatrists
The New York Times opinion writer, media commentator, outspoken Republican and Christian critic of the Trump presidency offers a spirited defense of politics and its virtuous and critical role in maintaining our democracy and what we must do to save it before it is too late. “Any nation that elects Donald Trump to be its president has a remarkably low view of politics.” Frustrated and feeling betrayed, Americans have come to loathe politics with disastrous results, argues Peter Wehner. In this timely manifesto, the veteran of three Republican administrations and man of faith offers a reasoned and persuasive argument for restoring “politics” as a worthy calling to a cynical and disillusioned generation of Americans. Wehner has long been one of the leading conservative critics of Donald Trump and his effect on the Republican Party. In this impassioned book, he makes clear that unless we overcome the despair that has caused citizens to abandon hope in the primary means for improving our world—the political process—we will not only fall victim to despots but hasten the decline of what has truly made America great. Drawing on history and experience, he reminds us of the hard lessons we have learned about how we rule ourselves—why we have checks and balances, why no one is above the law, why we defend the rights of even those we disagree with. Wehner believes we can turn the country around, but only if we abandon our hatred and learn to appreciate and honor the unique and noble American tradition of doing “politics.” If we want the great American experiment to continue and to once again prosper, we must once more take up the responsibility each and every one of us as citizens share.
This book offers expert, balanced, concise guidance on how clinicians can navigate a number of complex considerations to formulate a treatment plan for chronic pain that either includes or advisedly excludes opioids.
The successor to Strain and Stitzer's Methadone Treatment for Opioid Dependence (Johns Hopkins, 1999), this expanded and updated volume reflects new developments in treatment protocols. Methadone is still the most widely used medication for the treatment of opioid dependence, and the authors provide an extensive section on methadone treatment. Three chapters cover the pharmacology and clinical use of buprenorphine as well as the latest research on Naltrexone, Clonidine, and Lofexidine. The volume also includes chapters on pain and prescription opioids as well as medication-free treatment and medically supervised alternatives to opioid substitute treatments, including withdrawal. The Treatment of Opioid Dependence will be a valuable resource for methadone counselors, psychiatrists, psychologists, social workers, mental health nurses, and addiction counselors, as well as physicians interested in office-based buprenorphine treatment.
A first-of-its kind collection of the most vivid reporting about the most lethal addiction crisis ever Just a few years ago, the opioid crisis could be referred to as a "silent epidemic," but the scourge of opiate addiction is no longer being overlooked. This is in large part thanks to the extraordinary writings featured in this volume. Some of the mostimpactful reporting in the United States in recent years has addressed the opiate addiction crisis, a body of work that provides the best picture available of the origins, consequences, and human calamity associated with the epidemic. Now, for the first time, these key works of reportage and analysis have been collected in one volume, providing the fullest portrait available of this national tragedy. Numerous pieces in this groundbreaking collection have won major awards; many have changed the public conversation on opioids. American Epidemic gives readers the full story, with contributions from regional and national newspapers, prestige magazines, and leading literary journals. Spirited, informed, and eloquently written, American Epidemic will serve as an essential introduction for anyone seeking insight into the deadliest drug crisis our country has experienced.
When this series was conceived, a book on substance abuse, including alcohol and alcoholism, was to be of the highest priority. This priority was a reflection of my view that the subject is often inadequately or insufficient ly taught in many training programs. Few clinicians have had comprehen sive didactic education in this area, despite the frequency with which these problems are encountered in practice. All too often these encounters are in situations in which accurate diagnosis and rapid treatment are of critical im portance. We wanted a book that would be concise and easily readable but also comprehensive in its presentation of the basic principles underlying clinical manifestations, diagnosis, and management. It was of particular im portance that the book also serve as an easy reference guide in emergency situations. Marc Schuckit, a man with impeccable credentials as a scholar and an experienced clinician in this field, produced just such a book with his critically acclaimed first edition. That volume rapidly became a resource of great significance for psychiatrists, psychotherapists, and physicians in general. It has been adopted as a text in medical schools and residency train ing, as well as for courses in psychology, emergency medicine, social work, and nursing. The entire volume has been revised and updated to reflect changes in knowledge and clinical practice since the publication of the first edition and in order to keep the comprehensive references current. There is a new chapter on phencyclidine and another on caffeine and nicotine.
Containing more than 450 entries, this easy-to-read encyclopedia provides concise information about the history of and recent trends in drug use and drug abuse in the United States—a societal problem with an estimated cost of $559 billion a year. • Contains more than 450 detailed entries on topics ranging from drugs themselves—such as alcohol, codeine, heroin, marijuana, and methamphetamines—to key individuals like Harry Anslinger to organizations such as the Drug Enforcement Administration (DEA) • Covers the latest developments in U.S. policies and public attitudes toward drugs and drug use • Provides citations with each entry to guide users to other valuable research resources • Features carefully selected primary documents—including excerpts from important laws, policies, and campaigns—that have shaped American drug policy over the decades
No matter what questions arise in practice or while preparing for boards, Pain Management Secrets, 3rd Edition has the answers. A two-color page layout, portable size, and a list of the “Top 100 Secrets in pain management help you better meet the challenges you face today. You’ll find all the features you rely on from the Secrets Series®—a question-and-answer format, lists, mnemonics, tables and an informal tone—that make reference fast and easy. Expedites reference and review with a question-and-answer format, bulleted lists, mnemonics, and practical tips from the authors. Features a two-color page layout, "Key Points" boxes, and lists of useful web sites to enhance your reference power. Presents a chapter containing "Top 100 Secrets", providing you with an overview of essential material for last-minute study or self-assessment. Fits comfortably in the pocket of your lab coat so you have it conveniently on hand at all times. Features new editors, Charles E. Argoff, MD and Gary McCleane, MD who present a thorough update on the latest in pain management. Presents a new contemporary internal design that helps you navigate the text easier.
Regarded as the premiere clinical reference in its field, Pain Management, 2nd Edition, edited by noted pain authority Dr. Steven Waldman, provides comprehensive, practical, highly visual guidance to help you effectively apply the most recent evidence-based advances in pain management. This popular text has been updated with 13 new chapters that include the latest information on interventional and ultrasound-guided techniques, acute regional pain nerve blocks, and more. A user-friendly format with lavish illustrations enables you to access trusted guidance quickly...and apply the information easily...to bring effective pain relief to your patients. Tap into the experience of the book’s editor, Dr. Steven D. Waldman—author of numerous groundbreaking pain management references—and a diverse collection of leading international experts, many of whom are new to this edition. Effectively diagnose and manage any type of pain by implementing the latest, evidence-based approaches including interventional and ultrasound-guided techniques, and acute regional pain nerve blocks. Keep up with the most essential and latest topics with fully revised chapters and 13 new chapters that include information on central pain modulation, ultrasound-guided procedures, myelopathy, and more. Find the critical answers you need quickly and easily thanks to a templated format, with all content solely reviewed by Dr. Waldman to insure consistency throughout. Make more accurate diagnoses and perform nerve blocks successfully with unmatched guidance from 1100 full-color, large-scale illustrations.
IRVING LEVESON The 19608 was a period of rapid social and economic change, coupled with spectacular growth in the role of government in dealing with social issues. The demands of public programs and policies created enormous pressures for improved information and analyses. In the field of drug abuse these pressures were compounded by the rapid rise of drug use and the absence of much critical information and analysis. The most elementary steps to develop a data base were just beginning, and many years of effort would be required before the accumulation of knowledge could produce. a strong foundation for public policy. There has been enormous progress in improving knowledge about drug abuse since the mid-1960s. However, as in many fields, research has concentrated on a few questions while others largely are ignored, and even where studies exist there are problems of assimilation. Information is widely dispersed, not always accessible and often not in the most useful form. Many analysts do not have adequate understanding of the ways in which studies might enter into policy development, while at the same time, persons responsible for policy formation often do not have sufficient knowledge of how to use research to help resolve policy issues. A major objective of this volume is to illustrate the formation of linkages which may bridge the gap between research and policy.
This title includes additional digital media when purchased in print format. For this digital book edition, media content is not included. Prepare for exam success with Mosby's Review Questions for the NCLEX-RN® Examination! Over 5,000 exam-style practice questions help you assess your strengths and weaknesses, develop test-taking skills, and reduce your test anxiety. Written by testing experts Patricia M. Nugent, Phyllis K. Pelikan, Judith S. Green, and Barbara A. Vitale, this book makes review easy by organizing material into the core clinical areas of medical-surgical nursing, mental health, maternity, and pediatrics. Rationales are provided for both correct and incorrect answers, and alternate item format questions ensure that you're prepared for the latest version of the exam. Convenient organization by core clinical area, body system, and disorders makes it easy for students to select the practice questions they prefer. More than 3,000 questions in the book Rationales for both correct and incorrect answers explain the reasoning behind each answer option. Alternate item format questions include fill-in-the-blank, multiple response, drag and drop prioritizing, chart/exhibit, and hot spot (figure/illustration) enhance students' critical thinking skills. Three practice modes -- study, quiz, and exam Coverage of new content on the 2010 NCLEX-RN test plan prepares your students for the exam with the most up-to-date information. An increase to over 300 alternate item format questions provides additional practice with these important critical thinking questions. 12 chart/exhibit alternate item format questions introduce students to the newest alternate item format type. Coverage of new content on the 2010 NCLEX-RN test plan prepares you for the exam with the most up-to-date information. An increase to over 300 alternate item format questions provides additional practice with these important critical thinking questions. 12 chart/exhibit alternate item format questions introduce the newest alternate item format type.
Now in its sixth edition, Living with Drugs continues to be a well-respected and indispensable reference tool. Michael Gossop has updated this new edition to take account of new laws and practices that have come in to place since the previous edition, published in 2000. Written in an accessible style and providing a balanced perspective, the book is ideal for non-specialists in training, such as student nurses and social workers and for anyone with an interest in this complex, ever-present and emotive issue.
Opioid Therapy in the 21st Century, Second Edition provides clinicians with up-to-date, evidence-based information about appropriate opioid use, including the potential benefits and adverse affects of the therapy.